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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Fédération de recherche en infectiologie de la région Centre-Val de Loire

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Host pathogens relations in pigs

Director : François Meurens

Étude de deux pathogènes porcins d'importance pour l'animal et la santé publique : les virus Influenza et les Salmonelles


Les deux classes d'agents pathogènes : virus Influenza et salmonelle occasionnent des pertes économiques importantes dans la filière porcine. Agents d’anthropozoonoses, ces deux pathogènes constituent également un problème pour la santé des consommateurs.

Activités de recherche

Jusqu'en février 2010, les activités de l'équipe se sont portées principalement sur l'identification des facteurs humoraux et cellulaires impliqués dans le recrutement des populations lymphocytaires B et T dans la glande mammaire et la muqueuse intestinale porcine. Les mécanismes régulant la transmission de l'immunité passive via le colostrum et le lait, de la mère vers sa portée, ont également été abordés ainsi que le contrôle de la production des IgA en réponse à l'agression par le pathogène.
Les études de l'équipe sont maintenant plus particulièrement focalisées sur les deux agents pathogènes mentionnés ci-dessus avec une emphase particulière sur les relations qu’ils entretiennent avec l’hôte porcin dans les phases précoces de l’infection :

  • les virus Influenza comme modèle d’étude de la réponse innée de la muqueuse respiratoire ;
  • les salmonelles comme modèle d’étude de la réponse innée de la muqueuse digestive.

En outre, l’équipe développe des modèles porcins d’étude de pathologies humaines telles que notamment l’amibiase et la mucoviscidose.