How early metabolic response during viral infections influence disease outcomes?

How early metabolic response during viral infections influence disease outcomes?

21 October 2022

Clovis. S. Palmer from the Division of Comparative Pathology at Tulane National Primate Research Center (Covington, LA, USA) just released a review in "Nature metabolism" looking at how metabolism impacts immune cell function and outline how cell surface proteins that have been historically studied for their metabolic roles can serve as viral receptors and entry factors. It appears that metabolic adaptation to viral infections critically determines the course and manifestations of disease. The presumption that peripheral and tissue-specific ‘immune responses’ are the chief line of defence and regulate viral control is incomplete. Hypothesis are that metabolic engagements and metabolic reconfiguration of immune and non-immune cells following virus recognition modulate the natural course of viral infections. A greater understanding of immune response would lead to interventions that lower disease progression and help identify new and improved prognostic biomarkers.

Link to the article : https://www.nature.com/articles/s42255-022-00652-3