Know more

A recent article was published by the University of Belgrade in collaboration with the team "Multiresistance and Pathogenicity of Nematodes" (MPN) of the UMR ISP - INRAE ​​Nouzilly. They studied the action of carvacrol on Parascaris sp. and its antagonistic effect on nicotinic acetylcholine receptors. There is a real need for new therapies because these worms have developed resistance to the three main families of anthelmintics. Carvacol is a chemical compound found in the essential oil of origanum, thymus, coridothymus, thymbra, satureja and lippia herbs. This study focused on the characterisation of the mode of action of carvacol on the Parascaris sp. nicotinic acetylcholine receptor (nAChR) function. They developed a neuromuscular contraction test on body flaps of Parascaris and showed that the preparation of body muscle flaps appears to be an interesting approach to study the pharmacology of the neuromuscular system of Parascaris sp. The results suggest that this compound would be a potent antagonist of muscle nAChRs in these worms, which would explain its antiparasitic potency.

Link : https://www.mdpi.com/1424-8247/14/6/505/htm