New findings about how Mycobaterium bacteria interact with the immune system.

New findings about how Mycobaterium bacteria interact with the immune system.

18 March 2021

A multidisciplinary team led by researchers from The Francis Crick Institute and including University College Dublin, Public Health England, The Animal and Plant Health Agency and the Royal Veterinary College (RVC) studied how the bacteria that cause tuberculosis (TB) in humans and animals manipulate the host immune system to cause the disease. They found that, in vitro, only M.Bovis is able to induce multinucleated cell formation in bovine macrophages. The formation of multinucleated giant cells (MNGCs) is a hallmark of tuberculous pathology. They also identified that a protein of M.Bovis named MPB70 and bovine macrophage extracellular vesicles are acting as determinant factors for multinucleated cell formation.

Links: https://www.rvc.ac.uk/research/programmes/livestock-production-and-health/news/researchers-reveal-disease-mechanism-of-the-bovine-tb-pathogen

 https://doi.org/10.1371/journal.ppat.1009410

Modification date : 31 July 2023 | Publication date : 18 March 2021 | Redactor : Morgane Delavergne